Absorbable biodegradable polymers - Original PDF
نویسندگان: Shalaby W. Shalaby, Karen J.L. Burg
خلاصه: Egyptians sutured wounds as early as 3500 B.C. using a variety of natural
polymers including treated intestines, which are the early versions of collagen-based surgical gut sutures.1 Synthetic, absorbable polyesters based on 2-hydroxyacetic acids were developed for preparing less tissue reactive alternatives to surgical gut sutures in the early 1970s. In addition to collagenbased polymers, other natural, absorbable polymers, such as albumin, chitosan, and hyaluronic acid and derivatives thereof have been used for many
pharmaceutical and biomedical applications for several decades.2 Of these
polymers, the application of chitosan and hyaluronic acid–based polymers
has received a great deal of attention in the past 15 years for use in controlled
drug delivery systems, tissue repair, tissue engineering, and controlling certain biological events.