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Drug Transporters: Molecular Characterization and Role in Drug Disposition - PDF
Drug Transporters: Molecular Characterization and Role in Drug Disposition - PDF
نویسندگان: Guofeng You, Marilyn E. Morris, Binghe Wang خلاصه: A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition: * Provides a comprehensive overview of drug transporters * Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy * Describes transporter-mediated drug disposition, a newly emerging field in drug therapy * Gives a comprehensive summary of drug transport across biological membranes * in the liver, brain, kidney, and intestine * Provides balanced coverage of mechanistic aspects and functional outcomes * Features chapters contributed by distinguished scientists in their specialty areas * Provides sufficient detail to enable non-specialists to understand the principles and techniques This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.
The Minder Brain: How Your Brain Keeps You Alive, Protects You from Danger, and Ensures that You Reproduce - PDF
The Minder Brain: How Your Brain Keeps You Alive, Protects You from Danger, and Ensures that You Reproduce - PDF
نویسندگان: Joe Herbert خلاصه: Ambition, genius, thought, imagination, love, hate, greed and, above all, consciousness ourselves as alive and as part of our world all this is somehow enabled by the brain. The brain is the person, and if it goes wrong, a person is ruined. This book is about part of what the brain does a role of which many of us are hardly aware, but one that has ensured, the survival of mankind. Despite famine, drought, wars, cold, infections and hostile environments, we survive as a species though not always as individuals. All this time, our brains have been coping with what fate throws at us a process that some call adaptation. How does the brain do it? How does it know what s needed? How does it enable us to provide that need? How much do we depend on our own brains, or on those of others? This book is different from other books on the brain. It deals with the brain s role in survival, rather than higher cognitive functions (such as language or thought). It describes the special part of the brain that keeps you alive: that makes you feel hungry when you need energy, makes you feel thirsty when you need water, drives you to reproduce so that your species survives, makes you fearful of things or individuals that might harm you, and defends you against adversity.
You Failed Your Math Test, Comrade Einstein: Adventures and Misadventures of Young Mathematicians or Test Your Skills in Almost Recreational Mathematics - Original PDF
You Failed Your Math Test, Comrade Einstein: Adventures and Misadventures of Young Mathematicians or Test Your Skills in Almost Recreational Mathematics - Original PDF
نویسندگان: M. Shifman خلاصه: Interesting and tough problems from Moscow State University, Moscow Institute for Physics and Technology, and Moscow Institute for Engineering and Physics. Includes articles on the history of using tougher questions to refuse admission of Jewish students - a form of state-sanctioned discrimination, before the era of perestroika. There is also material covering the alleged KGB assassination of Bella Abramovna - a dedicated math teacher who organized an informal underground university for educating Jewish math students in the Soviet Union. A fascinating read.
The Long-Drive Bible: How You Can Hit the Ball Longer, Straighter, and More Consistently - Original PDF
The Long-Drive Bible: How You Can Hit the Ball Longer, Straighter, and More Consistently - Original PDF
نویسندگان: Sean Fister, Matthew Rudy, John Daly خلاصه: I bought the book before I Played in the Carolina Kids Classic with Beast. Interestingly enough even though his tips helped me I still couldn't get within a hundred yards of him. Super Ball is fun if you are on a par 4 in one and have a stroke.
The Well-Educated Mind: A Guide to the Classical Education You Never Had - Original PDF
The Well-Educated Mind: A Guide to the Classical Education You Never Had - Original PDF
نویسندگان: Susan Wise Bauer خلاصه: It was difficult to decide how many stars to give this book; three seemed a bit low, but four definitely seemed too high. The best part of this book is the suggested reading lists, complete with thumbnail descriptions: chronologically ordered lists of some of the most influential novels, autobiographies, histories, dramas, and poetry. I fully intend to use these lists to find future reading material. Less useful, at least to me, was the "instruction" in how to read "serious literature"; I find the suggestion that one cannot perform "logic-stage" and "rhetoric-stage" reading at the same time as "grammar-stage" reading, that one must take physical notes in a journal, and/or mark and dog-ear the pages of the book, in order to have truly read and understood it, to be somewhat patronizing and excessive. Yes, if a book is proving heavy going, these techniques might prove useful, but they are hardly universally essential when reading anything that somebody might consider "literature". Still, I suppose that it was necessary for the author to have something of the sort included, or all she would have had would have been a collection of suggested reading lists, which probably couldn't have been published. There was a lot of useful historical background here, as well, and the book was definitely worth the read. Still, I doubt that I'll be re-reading it any time soon, although I WILL be using the reading lists as reference material.
SELLING THE WHEEL: Choosing the Best Way to Sell For You, Your Company, and Your Customers - PDF
SELLING THE WHEEL: Choosing the Best Way to Sell For You, Your Company, and Your Customers - PDF
نویسندگان: Jeff Cox, Howard Stevens خلاصه: : I loved the book "Zapp!, The Lightening of Empowerment" co-authored by Jeff Coxx with William Byham... and it was that book that lead me to buying "Selling the Wheel." Selling the Wheel is a fun read, albeit a little too long. Jeff Cox has joined with Howard Stevens in this book and has retained the fable style writing from Zapp! which I am greatful for, as fables (for me) tend to deepen the teaching principles presented in the book. The principles are not earth-shattering in this book (focusing on individual selling styles of different sales people) though there are some timely lessons for people in business too. I liked it, but didn't love it. In that way it was a fun read... but not powerful.
Check Your English Vocabulary for Computers and Information Technology: All You Need to Improve Your Vocabulary - PDF
Check Your English Vocabulary for Computers and Information Technology: All You Need to Improve Your Vocabulary - PDF
نویسندگان: Jon Marks خلاصه: Designed to help non-native English speakers improve their knowledge and understanding of core computing terminology.
Just One Thing: Twelve of the World's Best Investors Reveal the One Strategy You Can't Overlook - PDF
Just One Thing: Twelve of the World's Best Investors Reveal the One Strategy You Can't Overlook - PDF
نویسندگان: John Mauldin خلاصه: In this book, John Mauldin offers an incomparable shortcut to prosperity: the personal guidance of an outstanding group of recognised financial experts, each offering the single most useful piece of advise garnered through years of investing. John Mauldin asked each contributor to share the single most useful insight gleamed from long years of experience: "just one thing". In this book you will learn: (1). How to boost returns with "the 2% alpha solution"?; (2). The risk-return fallacy; (3). Why you should use "volatility throttling" when assembling your portfolio; (4). The secret of "investing in the fog";(5). Why "the winner's rule" really works; (6). Why the best performing funds have the highest percentage of realised losses; (7). How psychology often trumps economics; and (8). The strength of a non consensus investment theme. Study and apply this book and you will get rich quickly.
Start with no: the negotiating tools that the pros don't want you to know - PDF
Start with no: the negotiating tools that the pros don't want you to know - PDF
نویسندگان: Jim Camp خلاصه: This is a great book on what is going on behind the scenes in negotiation, rather than simply providing a linear (and limiting) `how to'. Camp explains that negotiations should not be founded on the false pretense of win/win which implies compromise, sacrifice, and/or manipulation before negotiations have even begun. His system offers a thoughtful method to draw out the needs and desires of the adversary efficiently, while the contrarian slant helps shed new light on our undigested beliefs and assumptions about the process.
How to Talk to a Liberal (If You Must): The World According to Ann Coulter - Original PDF
How to Talk to a Liberal (If You Must): The World According to Ann Coulter - Original PDF
نویسندگان: Ann Coulter خلاصه: Ann's razor-sharp humor presents a scholarly view of the american liberal and how they should be safely handled when encountered. A perfect primer for the budding conservative.

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