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Drug Transporters: Molecular Characterization and Role in Drug Disposition - PDF
Drug Transporters: Molecular Characterization and Role in Drug Disposition - PDF
نویسندگان: Guofeng You, Marilyn E. Morris, Binghe Wang خلاصه: A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition: * Provides a comprehensive overview of drug transporters * Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy * Describes transporter-mediated drug disposition, a newly emerging field in drug therapy * Gives a comprehensive summary of drug transport across biological membranes * in the liver, brain, kidney, and intestine * Provides balanced coverage of mechanistic aspects and functional outcomes * Features chapters contributed by distinguished scientists in their specialty areas * Provides sufficient detail to enable non-specialists to understand the principles and techniques This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.
Ready Made Job Search Letters: Writing Letters and E-Mails to Help You Get Your Dream Job - PDF
Ready Made Job Search Letters: Writing Letters and E-Mails to Help You Get Your Dream Job - PDF
نویسندگان: Lynn Williams خلاصه: A well-written letter can help you to secure a job interview. It directs attention to your good points and away from your weaker ones, helping you to create the right impression and get your point across clearly and concisely. Whether you have considerable experience, are looking for a first job, or returning from a career break, you need to be able to write a professional, business-like letter. Your letter is the first thing that the employer sees, so the impression that they get at this stage will stay with them. This fully revised new edition of "Readymade Job Search Letters" gives advice on style, presentation, the best words to use, common mistakes to avoid, and writing effective email job applications. It will help you to make a favourable impression, inform, persuade and build a good relationship with the people you write to in order to get that interview. It also provides a wide selection of letters for different situations that can be adapted for individual use, such as: speculative enquiries to a company, requests for an introduction, replies to an advertised vacancy, applications for promotion, and cover letters for CVs. Punchy and informative and with supporting online downloadable sample letters, "Readymade Job Search Letters" is essential kit for any serious job-hunter.
Deal with Your Debt: The Right Way to Manage Your Bills and Pay Off What You Owe - Original PDF
Deal with Your Debt: The Right Way to Manage Your Bills and Pay Off What You Owe - Original PDF
نویسندگان: Liz Pulliam Weston خلاصه: Why do colleges cost so much? Large capital spending provide the best facilities, faculty, and sport centers and teams to keep wealth alumni donors happy. Universities hope to boost their national ranking by spending on high-speed internet access, new gyms, concert halls, and better student housing. Faculty salaries are expensive. The median salary for a tenure professor is $76,200. Many colleges are trying to shrink class sizes and reduce class loads so professors can do more research and bring glory to the University. What type of loans are available? A Perkins loan offers a 5% fixed interest rate and a maximum borrowed amount of $20,000. Stanford loan is a variable rate loan capped at 8.25% and a 4% upfront fee. How much should you borrow? None is the correct answer. If you don't have money then don't go to college. Save your money then go to college. If you yield to temptation and accept a loan then your loan payments once you graduate shouldn't exceed 10% of your expected monthly gross. You will have 10 years to repay the student loan. If you earn $40,000 then your payback will be 4,000 a year (10%) or about 340 dollars a month for a $26,000 dollar loan. The average undergraduate loan is about 26k. 50 percent of the student enrolled in college do not graduate and leave the college with heavy student debt. If you graduate making less than 40k the loan repayment amount will be overextended in ratio to earnings. Instead of 10 percent of your wages the loan will represent 15 to 20 percent. The heavier debt loan increases the risk of default.
Dealing with Statistics: What you need to know - Original PDF
Dealing with Statistics: What you need to know - Original PDF
نویسندگان: Reva Berman Brown, Mark Saunders خلاصه: ‘This is a highly accessible, yet an adequately sophisticated text, which can be enjoyed by students across the skills spectrum. I am confident that it will help students who suffer from maths phobia as it offers to teach statistics with anxiety-busting clarity. The book benefits from easy to follow demonstrations and illustrations of statistical methods and techniques, which are highly relevant for business and management research at the undergraduate and masters level courses.’ Professor Mustafa F. Ozbilgin, University of East Anglia, UK Are you confused about which statistical tests to use, when you should be using them and why you should be using them? This book is about helping you to choose and use the right statistical technique to analyse your data and write about your results and findings convincingly. It provides a concise and accessible guide to the essential statistical skills needed for success in your assignment, project or dissertation. Berman Brown and Saunders concentrate on particular statistical tests and their three Ws – what, why, and when. They provide you with the tools to choose the graphs and statistics that are suitable for your data, and to understand what the statistical results actually mean. In addition, the book: Explains why it is impossible to avoid using statistics in analysing data Describes the language of statistics to make it easier to understand the various terms used for statistical techniques Deals with using tables and charts to present data so that they are easy to understand Explains the statistics used to describe data used to infer differences and relationships. The book also includes a handy alphabet of statistics as well as a glossary of key statistical terms.
''Read you loud and clear!'': the story of NASA'S spaceflight tracking and data network - Original PDF
''Read you loud and clear!'': the story of NASA'S spaceflight tracking and data network - Original PDF
نویسندگان: Sunny Tsiao, National Aeronautics and Space Administration خلاصه: Regardless of how sophisticated it may be, no spacecraft is of any value unless it can be tracked accurately to determine where it is and how it is performing.At the height of the space race, 6,000 men and women operated NASA’s Spaceflight Tracking and Data Network at some two dozen locations across five continents. This network, known as the STDN, began its operation by tracking Sputnik 1, the world’s first artificial satellite that was launched into space by the former Soviet Union. Over the next 40 years, the network was destined to play a crucial role on every near-Earth space mission that NASA flew. Whether it was receiving the first television images from space, tracking Apollo astronauts to the Moon and back, or data acquiring for Earth science, the STDN was that intricate network behind the scenes making the missions possible. Some called it the “Invisible Network,” a hallmark of which was that no NASA mission has ever been compromised due to a network failure.Read You Loud and Clear! is a historical account of the STDN, starting with its formation in the late 1950s to what it is today in the first decade of the twenty-first century. It traces the roots of the tracking network from its beginnings at the White Sands Missile Range in New Mexico to the Tracking and Data Relay Satellite System (TDRSS) space-based constellation of today. The story spans the early days of satellite tracking using the Minitrack Network, through the expansion of the Satellite Tracking And Data Acquisition Network (STADAN) and the Manned Space Flight Network (MSFN), and finally, to the Space and Ground Networks of today.Written from a non-technical perspective, the author has translated a highly technical subject into historical accounts told within the framework of the U.S. space program. These accounts tell how international goodwill and foreign cooperation were crucial to the operation of the network and why the space agency chose to build the STDN the way it did. More than anything else, the story of NASA’s STDN is about the “unsung heroes of the space program.”
85 inspiring ways to market your small business: inspiring, self-help marketing strategies that you can apply to your own business immediately - PDF
85 inspiring ways to market your small business: inspiring, self-help marketing strategies that you can apply to your own business immediately - PDF
نویسندگان: Jackie Jarvis خلاصه: This book sets out to be your own, pocket, marketing consultant - without the expense. Not only does it offer some great ideas but it explains how each idea will benefit your business, what you need to do to make it work, and how you can apply it to your own business immediately. Through a series of special response questions it cleverly gets across marketing ideas in combination with the vital thinking behind their application. Furthermore, it does so in a way that transfers 'ownership' of these strategies to you the business manager so that you feel thoroughly motivated and inspired to act.Whether you run a product or service-led business, it will help you to: Understand your market place, your competition and your customer, Create solid, reasoned foundations for your business, Develop credible marketing messages that attract your target customer, Decide on the most effective marketing methods for your business, Attract new customers, and boost business with existing customers, Build your business profile so that it's always working for you, Sell yourself and your business with ease and confidence, Complete your marketing plan and create a successful marketing system. The ideas are presented separately in bite-sized chunks so that you can devote just a little thinking and reflection time to each one before - most importantly - making it all happen.
Network Warrior: Everything you need to know that wasn't on the CCNA exam - PDF
Network Warrior: Everything you need to know that wasn't on the CCNA exam - PDF
نویسندگان: Gary A. Donahue خلاصه: Written by networking veteran with 20 years of experience, Network Warrior provides a thorough and practical introduction to the entire network infrastructure, from cabling to the routers. What you need to learn to pass a Cisco certification exam such as CCNA and what you need to know to survive in the real world are two very different things. The strategies that this book offers weren
Real delegation: how to get people to do things for you - and do them well - PDF
Real delegation: how to get people to do things for you - and do them well - PDF
نویسندگان: J. K. Smart خلاصه: Overworked managers know that management is about doing the best you can with what you've got. This book blends the author's thinking framework with your individual experience to help you improve your delegation skills. Karen Smart's background is in individual and organizational development. However, unlike some in her field, first and foremost Karen sees herself as a line manager. In recent years, she's worked primarily on enabling managers to manage -- developing and delivering everything from individual skill building and management development programs to management systems design and organization wide culture change. In addition to managing her team, Karen has coached senior managers and facilitated cross-functional working, problem solving and conflict management. Although she has two degrees and has researched extensively across a range of disciplines, ultimately Karen feels she's learned most about management from her experience as an overworked and undervalued manager, disempowered by bureaucracy. From this experience - and inspired by the man she says "puts the J into KJ Smart and a lot of the smart too" - the philosophy of real management for real people was born.
Biosocial criminology : a primer (2nd Edition) - Scanned Pdf with Ocr
Biosocial criminology : a primer (2nd Edition) - Scanned Pdf with Ocr
نویسندگان: Kevin M. Beaver خلاصه: Biosocial criminology : a primer Author:Kevin M. Beaver
The Perfect Day to Boss Up: A Hustler's Guide to Building Your Empire - Epub + Coneverted Pdf
The Perfect Day to Boss Up: A Hustler's Guide to Building Your Empire - Epub + Coneverted Pdf
نویسندگان: Rick Ross خلاصه: The Perfect Day to Boss Up: A Hustler's Guide to Building Your Empire by Rick Ross (Author), Neil Martinez-Belkin

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