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Drug Transporters: Molecular Characterization and Role in Drug Disposition - PDF
Drug Transporters: Molecular Characterization and Role in Drug Disposition - PDF
نویسندگان: Guofeng You, Marilyn E. Morris, Binghe Wang خلاصه: A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition: * Provides a comprehensive overview of drug transporters * Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy * Describes transporter-mediated drug disposition, a newly emerging field in drug therapy * Gives a comprehensive summary of drug transport across biological membranes * in the liver, brain, kidney, and intestine * Provides balanced coverage of mechanistic aspects and functional outcomes * Features chapters contributed by distinguished scientists in their specialty areas * Provides sufficient detail to enable non-specialists to understand the principles and techniques This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.
The Minder Brain: How Your Brain Keeps You Alive, Protects You from Danger, and Ensures that You Reproduce - PDF
The Minder Brain: How Your Brain Keeps You Alive, Protects You from Danger, and Ensures that You Reproduce - PDF
نویسندگان: Joe Herbert خلاصه: Ambition, genius, thought, imagination, love, hate, greed and, above all, consciousness ourselves as alive and as part of our world all this is somehow enabled by the brain. The brain is the person, and if it goes wrong, a person is ruined. This book is about part of what the brain does a role of which many of us are hardly aware, but one that has ensured, the survival of mankind. Despite famine, drought, wars, cold, infections and hostile environments, we survive as a species though not always as individuals. All this time, our brains have been coping with what fate throws at us a process that some call adaptation. How does the brain do it? How does it know what s needed? How does it enable us to provide that need? How much do we depend on our own brains, or on those of others? This book is different from other books on the brain. It deals with the brain s role in survival, rather than higher cognitive functions (such as language or thought). It describes the special part of the brain that keeps you alive: that makes you feel hungry when you need energy, makes you feel thirsty when you need water, drives you to reproduce so that your species survives, makes you fearful of things or individuals that might harm you, and defends you against adversity.
You Failed Your Math Test, Comrade Einstein: Adventures and Misadventures of Young Mathematicians or Test Your Skills in Almost Recreational Mathematics - Original PDF
You Failed Your Math Test, Comrade Einstein: Adventures and Misadventures of Young Mathematicians or Test Your Skills in Almost Recreational Mathematics - Original PDF
نویسندگان: M. Shifman خلاصه: Interesting and tough problems from Moscow State University, Moscow Institute for Physics and Technology, and Moscow Institute for Engineering and Physics. Includes articles on the history of using tougher questions to refuse admission of Jewish students - a form of state-sanctioned discrimination, before the era of perestroika. There is also material covering the alleged KGB assassination of Bella Abramovna - a dedicated math teacher who organized an informal underground university for educating Jewish math students in the Soviet Union. A fascinating read.
Math You Can't Use: Patents, Copyright, and Software - PDF
Math You Can't Use: Patents, Copyright, and Software - PDF
نویسندگان: Ben Klemens خلاصه: Klemens provides an in-depth analysis of software patents and how they should be controlled, regulated and potentially discarded. Populated with engaging practical examples, this book should be read by anybody involved in software development, and in teaching future software developers.
The Long-Drive Bible: How You Can Hit the Ball Longer, Straighter, and More Consistently - Original PDF
The Long-Drive Bible: How You Can Hit the Ball Longer, Straighter, and More Consistently - Original PDF
نویسندگان: Sean Fister, Matthew Rudy, John Daly خلاصه: I bought the book before I Played in the Carolina Kids Classic with Beast. Interestingly enough even though his tips helped me I still couldn't get within a hundred yards of him. Super Ball is fun if you are on a par 4 in one and have a stroke.
God Wants You Dead - PDF
God Wants You Dead - PDF
نویسندگان: Sean Hastings, Paul Rosenberg خلاصه: one of the worst self help books I ever read. Don't waste your money or your time.
How to Make Anyone Fall in Love With You - Original PDF
How to Make Anyone Fall in Love With You - Original PDF
نویسندگان: Leil Lowndes خلاصه: Lowndes is an impressive author. Pity she cannot be objective. For her it is not ok to go after someone significantly better looking than yourself. But it is ok to go after someone significantly richer than yourself. A typical chick bias. Men - better get advice from your brothers Clink, La Ruina or Valentine. They are more on your side. Her: "Undercover Sex Signals" are great though.
Trade What You See: How To Profit from Pattern Recognition - PDF
Trade What You See: How To Profit from Pattern Recognition - PDF
نویسندگان: Larry Pesavento, Leslie Jouflas خلاصه: One of the best books I've read introducing Fibonacci levels, Gartley and butterfly patterns and even the basics of money management, trading plans and daily routine. This book is a must read for all beginning technical chart pattern traders.
Check Your English Vocabulary for TOEFL: All you need to pass your exams - PDF
Check Your English Vocabulary for TOEFL: All you need to pass your exams - PDF
نویسندگان: Rawdon Wyatt خلاصه: This workbook provides a resource for students studying for the TOEFL (Test of English as a Foreign Language) exam, which is required for non-native speakers of English wishing to study at many US universities and in other English-speaking countries. It includes a range of fun activities to help students build and improve their English vocabulary.
The Well-Educated Mind: A Guide to the Classical Education You Never Had - Original PDF
The Well-Educated Mind: A Guide to the Classical Education You Never Had - Original PDF
نویسندگان: Susan Wise Bauer خلاصه: It was difficult to decide how many stars to give this book; three seemed a bit low, but four definitely seemed too high. The best part of this book is the suggested reading lists, complete with thumbnail descriptions: chronologically ordered lists of some of the most influential novels, autobiographies, histories, dramas, and poetry. I fully intend to use these lists to find future reading material. Less useful, at least to me, was the "instruction" in how to read "serious literature"; I find the suggestion that one cannot perform "logic-stage" and "rhetoric-stage" reading at the same time as "grammar-stage" reading, that one must take physical notes in a journal, and/or mark and dog-ear the pages of the book, in order to have truly read and understood it, to be somewhat patronizing and excessive. Yes, if a book is proving heavy going, these techniques might prove useful, but they are hardly universally essential when reading anything that somebody might consider "literature". Still, I suppose that it was necessary for the author to have something of the sort included, or all she would have had would have been a collection of suggested reading lists, which probably couldn't have been published. There was a lot of useful historical background here, as well, and the book was definitely worth the read. Still, I doubt that I'll be re-reading it any time soon, although I WILL be using the reading lists as reference material.

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