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I can say that this has been the most helpful drug reference that a clinician can have, particularly if they are in a position where they are looked at to offer expertise on how to manage drug therapy. The sections on Patient Instructions, Adverse Reactions and monitoring parameters are especially useful, as are the notes and drug class charts.   What makes this such an incredible reference - particularly while participating on rounds - is how concise and informative it is, while putting each monograph into the context of what information is most helpful to your choice of agent and how to manage it. You are not only provided with information that is pertinent to the specific drug, but with information that contextualizes its proper use within each therapeutic category. Some bumpkin in the last edition's comments complained that patients are not prescribed classes of drugs, but individual drugs. That makes me curious as to how he decides to go with one medication over any other in that class.