لایب سان

Ebook details:
عنوان: Clinical Immunology and Serology A Laboratory Perspective
نویسنده: 9780803644663
ناشر: F.A. Davis Company; 4 edition (October 5, 2016)
زبان: English
شابک: 0803644663, 978-0803644663
حجم: 30 Mb
فرمت: True Pdf

Intro -- Inside Front Cover -- Title Page -- Copyright -- Dedication -- Preface -- Art Consultant -- Contributors -- Reviewers -- Acknowledgments -- Contents -- Section I Nature of the Immune System -- Chapter 1 Introduction to Immunity and the Immune System -- Immunity and Immunization -- Innate Versus Adaptive Immunity -- Cells of the Innate Immune System -- Cells of the Adaptive Immune System -- Organs of the Immune System -- Chapter 2 Nature of Antigensand the MajorHistocompatibilityComplex -- Factors Influencing the Immune Response -- Traits of Immunogens -- Epitopes -- Haptens -- Adjuvants -- Relationship of Antigens to the Host -- Major Histocompatibility Complex -- Chapter 3 Innate Immunity -- External Defense System -- Internal Defense System -- Chapter 4 Adaptive Immunity -- T-Cell Differentiation -- Stages in B-Cell Differentiation -- The Role of T Cells in the Adaptive Immune Response -- The Role of B Cells in the Adaptive Immune Response -- Laboratory Identification of Lymphocytes -- Chapter 5 Antibody Structure and Function -- Tetrapeptide Structure of Immunoglobulins -- The Nature of Light Chains -- Heavy-Chain Sequencing -- Hinge Region -- Three-Dimensional Structure of Antibodies -- Theories to Explain Antibody Diversity -- Genes Coding for Immunoglobulins -- Monoclonal Antibody -- Chapter 6 Cytokines -- Introduction to Cytokines -- Cytokines in the Innate Immune Response -- Cytokines in the Adaptive Immune Response -- Th17 Cytokines in Innate and Adaptive Immune Responses -- Hematopoietic Growth Factors -- Cytokine and Anticytokine Therapies -- Clinical Assays for Cytokines -- Chapter 7 Complement System -- Pathways of the Complement System -- System Controls -- Complement Receptors and Their Biological Roles -- Biological Manifestations of Complement Activation -- Complement and Disease States -- Complement Deficiencies. Laboratory Detection of Complement Abnormalities -- Section II Basic Immunology Procedures -- Chapter 8 Safety and Quality Management -- Laboratory Hazards -- Quality Management -- Regulatory Issues -- Quality Management Systems -- Chapter 9 Principles of Serological Testing -- Blood Specimen Preparation and Measuring -- Dilutions -- Chapter 10 Precipitation and Agglutination Reactions -- Antigen-Antibody Binding -- Precipitation Curve -- Measurement of Precipitation by Light Scattering -- Passive Immunodiffusion Techniques -- Electrophoretic Techniques -- Comparison of Precipitation Techniques -- Principles of Agglutination Reactions -- Types of Agglutination Reactions -- Instrumentation -- Quality Control and Quality Assurance -- Chapter 11 Immunoassays -- Formats for Labeled Assays -- Heterogeneous Versus Homogeneous Assays -- Radioimmunoassay -- Enzyme Immunoassays -- Fluorescent Immunoassays -- Chemiluminescent Immunoassays -- Chapte 12 Molecular Diagnostic Techniques -- Characteristics of Deoxyribonucleic Acid and Ribonucleic Acid -- Molecular Analysis -- DNA Sequencing -- Chapter 13 Flow Cytometry and Laboratory Automation -- Cell Flow Cytometry -- Immunoassay Automation -- Section III Immune Disorders -- Chapter 14 Hypersensitivity -- Type I Hypersensitivity -- Type II Hypersensitivity -- Type III Hypersensitivity -- Type IV Hypersensitivity -- Chapter 15 Autoimmunity -- Etiology of Autoimmune Disease -- Systemic Autoimmune Diseases -- Organ-Specific Autoimmune Diseases -- Chapte 16 Transplantation Immunology -- Histocompatibility Systems -- Allorecognition -- Transplant Rejection -- Graft-Versus-Host Disease (GVHD) -- Immunosuppressive Agents -- Clinical Histocompatibility Testing -- Chapter 17 Tumor Immunology -- Introduction to Tumor Biology -- Tumor Antigens -- Clinically Relevant Tumor Markers -- Laboratory Detection of Tumors. Interactions Between the Immune System and Tumors -- Immunoediting and Tumor Escape -- Immunotherapy -- Chapter 18 Immunoproliferative Diseases -- Malignant Transformation of Hematologic Cells -- Classification of Hematologic Malignancies -- Leukemias -- Lymphomas -- Plasma Cell Dyscrasias -- Role of the Laboratory in Evaluating Immunoproliferative Diseases -- Chapter 19 Immunodeficiency Diseases -- Clinical Effects of Primary Immunodeficiencies -- The Nine Categories of Primary Immunodeficiencies -- Laboratory Evaluation of Immune Dysfunction -- Section IV Serological and Molecular Diagnosis of Infectious Disease -- Chapter 20 Serological and Molecular Detection of Bacterial Infections -- Human-Microbe Relationships -- Bacterial Virulence Factors -- Immune Defenses Against Bacterial Infections and Mechanisms of Evasion -- Laboratory Detection and Diagnosis of Bacterial Infections -- Group A Streptococci -- Helicobacter -- Mycoplasma Pneumoniae -- Chapter 21 Spirochete Diseases -- Syphilis -- Lyme Disease -- Relapsing Fever Group-Borrelia Miyamotoi -- Chapter 22 Serological and Molecular Diagnosis of Parasitic and Fungal Infections -- Parasitic Immunology -- Fungal Immunology -- Chapter 23 Serology and Molecular Detection of Viral Infections -- Immune Defenses Against Viral Infections -- Viral Escape Mechanisms -- Laboratory Testing for Viral Infections -- Hepatitis Viruses -- Herpes Virus Infections -- Other Viral Infections -- Chapter 24 Laboratory Diagnosis of HIV infection -- HIV Transmission -- Characteristics of HIV -- Immunologic Manifestations -- Clinical Symptoms of HIV Infection -- Treatment and Prevention -- Laboratory Testing for HIV Infection -- Screening and Diagnosis -- Disease Monitoring -- Testing of Infants Younger Than 18 Months -- Chapter 25 Immunization and Vaccines -- Vaccines -- Passive Immunization -- Adoptive Immunotherapy. Glossary -- References -- Answer Key -- Index.

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